منابع مشابه
The electrophysiologic effects of quinidine in the transplanted human heart.
Using His bundle recording techniques, we examined direct and autonomically mediated conduction system effects of quinidine in five cardiac transplant recipients who have anatomically denervated hearts. We made control conduction interval and refractory period measurements, and then infused 10 mg/kg quinidine gluconate over a 20-min period. At 30 min, we determined the electrophysiologic change...
متن کاملElectrophysiologic effects of quinidine. Studies using chronically implanted electrodes in awake dogs with and without cardiac denervation.
Experiments were performed on awake dogs with chronic recording electrodes implanted on the SA node, His bundle, and right bundle branch. Quinidine at serum concentrations of 5 to 10 mg/ liter had little effect on AV conduction, but slowed conduction in Purkinje tissue, prolonged ventricular activation, decreased the excitability of atrium and ventricle, and prolonged the atrial refractory peri...
متن کاملElectrophysiologic Effects of Disopyramide Phosphate
The electrophysiologic effects of intravenously administered disopyramide (2 mg/kg) on three parameters of sinus node function were examined in 16 symptomatic patients with sinus node dysfunction. Based on their ECG data before study, patients were subdivided into group A (n = 8), those with sinus pauses and/or sinoatrial (SA) exit block; and group B (n = 8), those with sinus bradycardia. Disop...
متن کاملClinical electrophysiologic effects of tocainide.
The electrophysiologic properties of tocainide were evaluated by electrophysiologic studies in 11 patients before, during and after a constant intravenous infusion of the drug for 15 minutes. Peak plasma tocainide concentrations averaged 11.0 +/- 1.7 microgram/ml (SEM), range 3.7 to 22.7. AH, HV, QRS, QTc and RR intervals were measured every 5 minutes during sinus and atrial-paced rhythms and s...
متن کاملMexiletine-quinidine combination: electrophysiologic correlates of a favorable antiarrhythmic interaction in humans.
Combination therapy with mexiletine and quinidine has been shown to be more effective than either agent alone. The ability of mexiletine monotherapy, quinidine monotherapy and mexiletine-quinidine combination therapy to suppress inducible sustained ventricular tachycardia was related to drug-induced changes in ventricular refractoriness, conduction times and monophasic action potential duration...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1966
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.19.5.960